If you love bold flavors and creamy pasta dishes, this Amazing Cajun Beef Spaghetti with Three-Cheese Sauce will quickly become a favorite. This delicious recipe pairs spicy Cajun-seasoned beef with a rich blend of Parmesan, mozzarella, and cheddar cheese sauce, all served over perfectly cooked spaghetti. It’s a wonderful combination that delivers comfort and excitement in every bite.
Thank you for reading this post, don't forget to subscribe!Table of Contents
Why You’ll Enjoy This Cajun Beef Spaghetti
Cajun Beef Spaghetti is perfect for busy nights when you want a hearty yet easy meal. Ready in just 30 minutes, this recipe brings together creamy textures and savory seasonings quickly and effortlessly. The Cajun spices give the spaghetti a vibrant kick that balances the indulgence of the melted cheese sauce, making it an ideal dish for family dinners or casual gatherings.

Amazing Cajun Beef Spaghetti with Three-Cheese Sauce
Ingredients
Equipment
Method
- Boil salted water and cook spaghetti according to package instructions until al dente. Drain well and toss with a little olive oil to prevent sticking.
- In a hot skillet, brown the ground beef in olive oil for about 5–7 minutes, breaking it apart as it cooks. Drain any excess fat.
- Add Cajun seasoning, garlic powder, onion powder, salt, and pepper to the browned beef. Stir and cook for 2 minutes to blend flavors.
- Reduce heat and pour in heavy cream. Add Parmesan, mozzarella, and cheddar cheeses, stirring continuously until melted and creamy.
- Add cooked spaghetti to the cheese sauce and toss to coat. Heat for 2–3 minutes until warmed through.
- Serve hot, garnished with chopped green onions for a fresh flavor finish.
Nutrition
Notes
Tried this recipe?
Let us know how it was!Ingredients for Cajun Beef Spaghetti
Main Components
- 8 ounces spaghetti
- 1 pound ground beef (try ground turkey or chicken for a healthier twist)
Seasonings and Spices
- 1 tablespoon Cajun seasoning
- 1 teaspoon garlic powder
- 1 teaspoon onion powder
- 1/2 teaspoon black pepper
- 1/4 teaspoon salt
Sauce Ingredients
- 1 tablespoon olive oil
- 1 cup heavy cream (or substitute Greek yogurt mixed with low-fat milk)
- 1/2 cup grated Parmesan cheese
- 1/2 cup shredded mozzarella cheese
- 1/2 cup shredded cheddar cheese
Garnish
- 1/4 cup chopped green onions for a fresh finish

Step-by-Step Guide
Step 1 – Cook the Spaghetti
Boil salted water and cook spaghetti according to package instructions until al dente. Drain well, then toss with a little olive oil to prevent sticking.
Step 2 – Brown the Beef
In a hot skillet, brown the ground beef in olive oil, breaking it apart as it cooks for about 5-7 minutes. Remove excess fat for a leaner dish.
Step 3 – Season the Beef
Add Cajun seasoning, garlic powder, onion powder, salt, and pepper to the browned beef. Stir well and cook for 2 minutes to blend the flavors.
Step 4 – Make the Cheese Sauce
Reduce the heat and pour in heavy cream. Add Parmesan, mozzarella, and cheddar cheeses. Stir continuously until the cheese melts into a creamy sauce.
Step 5 – Combine and Finish
Add the cooked spaghetti to the cheese sauce, tossing gently to coat every strand. Heat for 2-3 minutes to warm through.
Step 6 – Garnish and Serve
Serve hot, garnished with chopped green onions for a burst of fresh flavor and color.

Pro Tips for Perfect Cajun Beef Spaghetti
- Salt the pasta water generously to enhance flavor.
- Use low heat to melt cheese smoothly without scorching.
- Brown beef thoroughly to deepen the dish’s flavor.
- Adjust Cajun seasoning to your preferred spice level.
- Fresh cheeses improve taste and texture noticeably.
Flavor Variations for Cajun Beef Spaghetti
- Swap beef for mushrooms or lentils for a vegetarian version.
- Add greens like spinach or kale just before serving.
- Choose gluten-free pasta for dietary restrictions.
- Include jalapeños or hot sauce for extra spice.
Serving Suggestions
Pair this Cajun beef spaghetti with crunchy garlic bread or a crisp green salad dressed in light vinaigrette to balance the richness.

Storage Tips
Store leftovers in an airtight container in the fridge for up to three days. Reheat gently, adding a splash of milk or cream to restore creaminess. Avoid freezing to maintain the sauce’s texture.
Nutrition Information Per Serving
| Calories | Protein | Carbs | Fat | Fiber | Sodium |
|---|---|---|---|---|---|
| 570 | 35g | 30g | 35g | 2g | 600mg |
Frequently Asked Questions About Cajun Beef Spaghetti
Can I prepare Cajun beef spaghetti in advance?
Yes, cook the pasta and sauce separately ahead of time. Store refrigerated and combine before serving, reheating gently.
What’s a good substitute for heavy cream in this dish?
Half-and-half or a yogurt and milk blend works well for a lighter sauce.
How spicy is this Cajun beef spaghetti?
The spice depends on the Cajun seasoning used. Adjust quantity or add jalapeños for desired heat.
Can I use different types of pasta?
Yes, penne, fettuccine, or gluten-free noodles all make great alternatives.
How do I store leftovers?
Keep refrigerated up to three days in an airtight container, reheating gently with cream or milk.
Final Thoughts
This Cajun Beef Spaghetti with Three-Cheese Sauce offers a flavorful and creamy pasta dinner that’s quick and satisfying. Its balance of spices, creamy cheese, and hearty beef makes it a great choice for any night of the week.
Ready to enjoy a fresh and satisfying meal? Try making this Chicken Caesar Pasta Salad today! Packed with tender chicken, crisp greens, and creamy dressing, it’s the perfect dish for easy lunches or light dinners.
For detailed nutrition data on ingredients like beef, cheese, and pasta, explore the official USDA FoodData Central database, a trusted government source for accurate food information. Click here to start your delicious and nutritious Chicken Caesar Pasta Salad journey now!